eISSN: 1643-3750


Published: 2017-05-29

The Impact of Obesity on the Clinical Course of Inflammatory Bowel Disease: A Meta-Analysis

Qiongyuan Hu, Jianan Ren, Guanwei Li, Xiuwen Wu, Jieshou Li

(Department of Surgery, Jinling Hospital, Medical School of Southeast University, Nanjing, Jiangsu, China (mainland))

Med Sci Monit 2017; 23:2599-2606

DOI: 10.12659/MSM.901969

BACKGROUND: Obesity has been linked with a pro-inflammatory state and the development of inflammatory diseases, including inflammatory bowel disease (IBD). However, there is some controversy regarding whether obesity is associated with an adverse clinical course in patients with IBD. The aim of this meta-analysis was to assess the association between obesity and clinical outcomes in IBD patients.
MATERIAL AND METHODS: Electronic databases (PubMed, Embase, Cochrane Library, and Web of Science) were systematically searched for studies investigating the association between obesity and clinical outcomes in patients with IBD. A meta-analysis was performed using Review Manager software.
RESULTS: Among the 4,798 articles identified, seven met the inclusion criteria for our meta-analysis. The pooled data revealed that obese patients were significantly less likely to undergo IBD-related surgery, receive hormone therapy, and experience hospitalization compared with non-obese patients. However, no statistically significant difference was observed in perianal disease, anti-TNF use, and immunomodulator use between the two groups.
CONCLUSIONS: Our meta-analysis indicated that clinical outcomes were significantly different in obese versus non-obese patients with IBD. We found that obesity was associated with a less severe disease course of IBD. Future prospective studies are needed to confirm the relationship between obesity and the clinical course of IBD.

Keywords: Anastomosis, Surgical, Inflammatory Bowel Diseases, Obesity, Abdominal

Published: 2017-05-28

Zinc Finger E-Box Binding Protein 2 (ZEB2) Suppress Apoptosis of Vascular Endothelial Cells Induced by Hi...

Lin-Jun Wang, Zi-Heng Wu, Xiang-Tao Zheng, Jian-Yun Long, Yang-Min Dong, Xin Fang

Med Sci Monit 2017; 23:2590-2598

DOI: 10.12659/MSM.904678

Published: 2017-05-28

Association Between ABO Blood Type and Postoperative Cognitive Dysfunction in Elderly Patients Undergoing...

Jie Li, Jun Zhou, Yunqiang Wan, Li Liu, Cehua Ou

Med Sci Monit 2017; 23:2584-2589

DOI: 10.12659/MSM.901736